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Stereoselective Synthesis of Borylated 1,3‐Dienes by Synergistic Cu/Pd Catalysis
Author(s) -
VázquezGaliñanes Nuria,
FañanásMastral Martín
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201801240
Subject(s) - chemistry , catalysis , stereoselectivity , combinatorial chemistry , enantioselective synthesis , reaction conditions , medicinal chemistry , organic chemistry
A Cu/Pd‐catalyzed alkenylboration of alkynes with alkenyl bromides and bis(pinacolato)diboron is reported. This transformation features the generation of a catalytic β‐boryl‐substituted C(sp 2 )‐Cu intermediate and subsequent Pd‐catalyzed cross‐coupling. The reaction tolerates a wide array of substrates and affords diversely substituted syn ‐borylated 1,3‐dienes under mild conditions with total regio‐ and stereocontrol.
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