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Cover Feature: In Vitro One‐Pot Enzymatic Synthesis of Hyaluronic Acid from Sucrose and N ‐Acetylglucosamine: Optimization of the Enzyme Module System and Nucleotide Sugar Regeneration (ChemCatChem 14/2018)
Author(s) -
Eisele Anna,
Zaun Henning,
Kuballa Jürgen,
Elling Lothar
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201801075
Subject(s) - nucleotide sugar , biochemistry , sucrose , n acetylglucosamine , chemistry , monosaccharide , enzyme , chitin , sugar , nucleotide , hyaluronic acid , chitosan , glycosyltransferase , biology , genetics , gene
The Cover Feature shows how hyaluronic acid can be easily prepared in one pot using sugar (sucrose) and N ‐acetylglucosamine (from chitin of shrimps) as main ingredients, a tin of nucleotide energy, a pinch of metal salts, and, most important, a handful of fresh enzymes. In their Full Paper, A. Eisele et al. present a recipe of highly defined, optimized reaction conditions for the multi‐enzymatic synthesis of high molecular weight (2–3 MDa) hyaluronic acid from sustainable substrates with regeneration of activated monosaccharides (nucleotide sugars). More information can be found in the Full Paper by A. Eisele et al. on page 2969 in Issue 14, 2018 (DOI: 10.1002/cctc.201800370).