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Front Cover: Enhancing the Catalytic Performance of a CYP116B Monooxygenase by Transdomain Combination Mutagenesis (ChemCatChem 14/2018)
Author(s) -
Li RenJie,
Xu JianHe,
Chen Qi,
Zhao Jing,
Li AiTao,
Yu HuiLei
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201801074
Subject(s) - mutagenesis , monooxygenase , tetralin , cover (algebra) , chemistry , site directed mutagenesis , substrate (aquarium) , front cover , catalysis , mutation , biochemistry , enzyme , biology , engineering , ecology , mutant , mechanical engineering , cytochrome p450 , gene
The Front Cover illustrates the evolution process of P450 LaMO by transdomain combination mutagenesis as different branches of an army joining forces triumphantly atop the Great Wall. In their Full Paper, R.‐J. Li et al. met the great challenge of enhancing turnover, frequency and electron coupling efficiency of a CYP1168 monooxygenase for the unnatural substrate tetralin by introducing mutagenesis simultaneously into the heme domain and the redox domain of P450 LaMO . More information can be found in the Full Paper by R.‐J. Li et al. on page 2962 in Issue 14, 2018 (DOI: 10.1002/cctc.201800054).