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Aerobic Activation of C‐H Bond in Amines Over a Nanorod Manganese Oxide Catalyst
Author(s) -
Wang Hai,
Wang Liang,
Wang Sai,
Dong Xue,
Zhang Jian,
Xiao FengShou
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201801058
Subject(s) - catalysis , chemistry , nitrile , dehydrogenation , amide , manganese , hydrolysis , nanorod , amine gas treating , organic chemistry , manganese oxide , oxide , combinatorial chemistry , materials science , nanotechnology
Abstract The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chemistry research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR‐MnO x ) catalyst. The kinetic studies reveal that the NR‐MnO x catalyzed amine‐to‐amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR−MnO x exhibits fast kinetics and high selectivities in these steps, as well as hinders the by‐product formation. More importantly, the NR‐MnO x catalyst is stable and reusable in the continuous recycle tests with water as a sole by‐product, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic by‐products.