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Peptide‐Gold Nanoparticle Conjugates as Sequential Cascade Catalysts
Author(s) -
Mikolajczak Dorian J.,
Koksch Beate
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800961
Subject(s) - chemistry , combinatorial chemistry , biocatalysis , catalysis , colloidal gold , peptide , substrate (aquarium) , conjugate , nanoparticle , cooperativity , enzyme catalysis , esterase , organic chemistry , enzyme , nanotechnology , materials science , reaction mechanism , biochemistry , mathematical analysis , oceanography , mathematics , geology
Combining bio‐ and chemocatalysis in one pot is a challenging task due to the necessity to ensure compatible reaction conditions, as well as reagent tolerance, for the catalytic components. Here we present a peptide‐gold nanoparticle conjugate that combines esterase (biocatalysis) and hydrogenation (chemocatalysis) activities under the same set of aqueous reaction conditions. The self‐assembled peptide‐monolayer acts as an esterase mimic and shows positive cooperativity in substrate binding, an important feature used by nature to regulate catalytic activities of enzymes. The gold nanoparticle surface catalyzes the reduction of a nitro‐containing substrate to an amine product. This study opens up a new avenue in the design of peptide‐metal nanoparticle catalysts with enzyme‐like properties for efficient one‐pot reactions.