Premium
Novel Insights into the Combination of Metal‐ and Biocatalysis: Cascade One‐Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents
Author(s) -
Paris Juraj,
RíosLombardía Nicolás,
Morís Francisco,
Gröger Harald,
GonzálezSabín Javier
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800768
Subject(s) - biocatalysis , eutectic system , palladium , chemistry , catalysis , substrate (aquarium) , enantiomer , enantiomeric excess , cascade , combinatorial chemistry , biotransformation , enantioselective synthesis , metal , organic chemistry , ionic liquid , enzyme , chromatography , oceanography , alloy , geology
One of the pioneering examples of chemoenzymatic cascades in water such as the palladium‐catalysed Suzuki‐cross coupling followed by an enzymatic reduction has been revisited by the employment of a medium containing Deep Eutectic Solvents ( DESs ) for the catalytic performance. Thus, the unique properties of these neoteric solvents enabled to reach high substrate concentration for the overall process. Moreover, both isolated enzymes and whole cells exhibited excellent activities which allowed to obtain a set of chiral biaryl alcohols in good yields and very high enantiomeric excess (>99 %).