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A Recyclable Hydrophobic Anchor‐Tagged Asymmetric Amino Thiourea Catalyst
Author(s) -
Jichu Takahisa,
Inokuma Tsubasa,
Aihara Keisuke,
Kohiki Taiki,
Nishida Kodai,
Shigenaga Akira,
Yamada Kenichi,
Otaka Akira
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800714
Subject(s) - thiourea , catalysis , chemistry , organic chemistry , hydrophobic effect , organocatalysis , combinatorial chemistry , enantioselective synthesis
A novel, recyclable, thiourea‐based asymmetric organocatalyst containing a hydrophobic anchor has been developed. The chemical nature of the hydrophobic anchor contributes to the desirable characteristics of the recyclable catalyst. The hydrophobic anchor‐tagged thiourea catalyst is highly soluble in less polar solvents, which is compatible with amino thiourea catalyst‐mediated asymmetric reaction conditions, but sparingly soluble in polar solvents used for the recycle process. This asymmetric catalyst delivers a catalytic performance comparable to that of a parent catalyst and can be readily recycled from reactions.