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Rhenium‐ and Manganese‐Catalyzed Selective Alkenylation of Indoles
Author(s) -
Wang Chengming,
Rueping Magnus
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800553
Subject(s) - regioselectivity , rhenium , manganese , catalysis , chemistry , combinatorial chemistry , organic chemistry
An efficient rhenium‐catalyzed regioselective C−H bond alkenylation of indoles is reported. The protocol operates well for internal as well as terminal alkynes, affording products in good to excellent yields. Furthermore, a manganese‐catalyzed, acid free, regioselective C2‐alkenylation of indoles with internal alkynes is described. The directing groups can be easily removed after the reaction and the resulting products can be used as valuable building blocks for the synthesis of diverse heterocyclic compounds.