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Front Cover: Surface‐Binding Peptide Facilitates Electricity‐Driven NADPH‐Free Cytochrome P450 Catalysis (ChemCatChem 3/2018)
Author(s) -
Zernia Sarah,
Frank Ronny,
Weiße Renato H.J.,
Jahnke HeinzGeorg,
BellmannSickert Kathrin,
Prager Andrea,
Abel Bernd,
Sträter Norbert,
Robitzki Andrea,
BeckSickinger Annette G.
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800089
Subject(s) - chemistry , peptide , cytochrome p450 , cytochrome c , indium tin oxide , catalysis , front cover , electrocatalyst , combinatorial chemistry , enzyme , biochemistry , cover (algebra) , organic chemistry , electrochemistry , electrode , apoptosis , layer (electronics) , mechanical engineering , engineering
The Front Cover displays the immobilization of cytochrome P450 BM3 on metals mediated by a binding peptide, which enables the energization of the enzyme with electric potential to facilitate electrocatalysis on different substrates. In their Full Paper, S. Zernia et al. demonstrate that a recombinant fusion of an indium tin oxide binding peptide and the multi‐domain class VIII cytochrome P450 BM3 allows for a direct electron supply. Furthermore, it was shown that this approach is also feasible for pharmaceutical application. More information can be found in the Full Paper by S. Zernia et al. on page 525 in Issue 3, 2018 (DOI: 10.1002/cctc.201701810).