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Direct C(sp 2 )−H Hydroxylation of Arenes with Palladium(II)/Oxygen Using Sulfoximines as a Recyclable Directing Group
Author(s) -
Das Prasenjit,
Guin Joyram
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800064
Subject(s) - hydroxylation , autoxidation , palladium , chemistry , molecular oxygen , catalysis , phenols , aldehyde , oxygen , organic chemistry , combinatorial chemistry , enzyme
The aerobic palladium(II) catalysis presented herein offers facile entry to various substituted phenols through site‐selective C−H hydroxylation of arenes by using sulfoximines as a reusable directing group. The notable aspects of our method include the use of molecular oxygen (O 2 ) as the sole oxidant, the activation of molecular oxygen through aldehyde autoxidation, operational simplicity, and the mechanistic studies into the catalytic C−H hydroxylation process.