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Cover Feature: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree—Biochemical and Structural Studies (ChemCatChem 2/2018)
Author(s) -
Lorenzen Jan,
Driller Ronja,
Waldow Ayk,
Qoura Farah,
Loll Bernhard,
Brück Thomas
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201800008
Subject(s) - chemistry , rhodococcus , monomer , oleic acid , enzyme , biochemistry , stereochemistry , organic chemistry , polymer
The Cover Feature displays the crystal structure of the oleate hydratase OhyRe from Rhodococcus erythropolis , structurally and biochemically characterized for the first time, which catalyzes the hydration and dehydration of oleic acid. In their Full Paper, J. Lorenzen, R. Driller et al. elucidated the crystal structure of OhyRe, which revealed that the active form of OhyRe is a monomer, in contrast to other known oleate hydratase structures. Mutation of key residues resulted in decreased enzymatic activity, indicating a distinct reaction mechanism among the family members of hydratases. More information can be found in the Full Paper by J. Lorenzen, R. Driller et al. on page 407 in Issue 2, 2018 (DOI: 10.1002/cctc.201701350).