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Photocatalytic Regulation of an Autocatalytic Wave of Spatially Propagating Enzymatic Reactions
Author(s) -
Lanchuk Yulia,
Nikitina Anna,
Brezhneva Nadzeya,
Ulasevich Sviatlana A.,
Semenov Sergey N.,
Skorb Ekaterina V.
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201702005
Subject(s) - autocatalysis , photocatalysis , chemistry , autocatalytic reaction , quenching (fluorescence) , chemical reaction , photochemistry , chemical engineering , nanotechnology , materials science , catalysis , fluorescence , organic chemistry , physics , statistical physics , quantum mechanics , engineering
Bioinspiration is an attractive way to develop new robust chemistry. In biological cell, chemical reactions form complex networks (e.g. signaling and metabolic) that communicate with each other and control cell division, growth, and interaction with environment. Thus, combining multiple chemical subsystems into a single network is an attractive way to design a chemical system with new functions. In this paper, we combined two chemical networks: i) a photocatalytic oxidation/ reduction on TiO 2 particles, and ii) an autocatalytic formation of enzyme trypsin ( Tr ) from its precursor trypsinogen ( Tg ). Moreover, we put the combined network in hydrogel media, where all reactions are coupled to diffusion, to achieve a photocatalytic regulation of an autocatalytic wave. We showed that TiO 2 particles affected the fluorescence quenching of Tr , but, without irradiation, had no effect on the autocatalytic formation of Tr . With irradiation, however, a cascade of photocatalytic reactions causes media acidification that suppress the autocatalytic formation of Tr and propagation of the autocatalytic wave.