Ring‐Expanded N‐Heterocyclic Carbenes for Copper‐Mediated Azide–Alkyne Click Cycloaddition Reactions | Zendy

Sebest Filip | Zendy; Dunsford Jay J. | Zendy; Adams Matthew | Zendy; Pivot Jeremy | Zendy; Newman Paul D. | Zendy; DíezGonzález Silvia | Zendy

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Ring‐Expanded N‐Heterocyclic Carbenes for Copper‐Mediated Azide–Alkyne Click Cycloaddition Reactions

Author(s) -

Sebest Filip,

Dunsford Jay J.,

Adams Matthew,

Pivot Jeremy,

Newman Paul D.,

DíezGonzález Silvia

Publication year - 2018

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201701992

Subject(s) - cycloaddition , azide , alkyne , click chemistry , chemistry , ring (chemistry) , copper , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis

A series of well‐defined copper(I) complexes bearing ring‐expanded N‐heterocyclic carbene (NHC) ligands has been applied to the azide–alkyne cycloaddition reaction. The obtained results notably showed that the six‐membered NHC ligands outperform well‐established five‐membered ones. [CuI(Mes‐6)] displayed a remarkable catalytic activity while respecting the strict criteria for click reactions.

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