Premium
Ring‐Expanded N‐Heterocyclic Carbenes for Copper‐Mediated Azide–Alkyne Click Cycloaddition Reactions
Author(s) -
Sebest Filip,
Dunsford Jay J.,
Adams Matthew,
Pivot Jeremy,
Newman Paul D.,
DíezGonzález Silvia
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701992
Subject(s) - cycloaddition , azide , alkyne , carbene , click chemistry , chemistry , ring (chemistry) , copper , medicinal chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry
A series of well‐defined copper(I) complexes bearing ring‐expanded N‐heterocyclic carbene (NHC) ligands has been applied to the azide–alkyne cycloaddition reaction. The obtained results notably showed that the six‐membered NHC ligands outperform well‐established five‐membered ones. [CuI(Mes‐6)] displayed a remarkable catalytic activity while respecting the strict criteria for click reactions.