Continuous‐Flow Palladium‐Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source | Zendy

Valentini Federica | Zendy; Santillo Niccolò | Zendy; Petrucci Chiara | Zendy; Lanari Daniela | Zendy; Petricci Elena | Zendy; Taddei Maurizio | Zendy; Vaccaro Luigi | Zendy

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Continuous‐Flow Palladium‐Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source

Author(s) -

Valentini Federica,

Santillo Niccolò,

Petrucci Chiara,

Lanari Daniela,

Petricci Elena,

Taddei Maurizio,

Vaccaro Luigi

Publication year - 2018

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201701922

Subject(s) - sodium formate , cyclohexanone , catalysis , palladium , chemistry , yield (engineering) , formate , phenol , selectivity , hydrogen production , hydrogen , inorganic chemistry , organic chemistry , materials science , metallurgy

We report a procedure for the continuous‐flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass‐derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min −1 , we achieved continuous‐flow production of cyclohexanone in high yield with high selectivity and productivity.

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