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Continuous‐Flow Palladium‐Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source
Author(s) -
Valentini Federica,
Santillo Niccolò,
Petrucci Chiara,
Lanari Daniela,
Petricci Elena,
Taddei Maurizio,
Vaccaro Luigi
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701922
Subject(s) - sodium formate , cyclohexanone , catalysis , palladium , chemistry , yield (engineering) , formate , phenol , selectivity , hydrogen production , hydrogen , inorganic chemistry , organic chemistry , materials science , metallurgy
Abstract We report a procedure for the continuous‐flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass‐derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min −1 , we achieved continuous‐flow production of cyclohexanone in high yield with high selectivity and productivity.