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Direct Synthesis of Lactams from Keto Acids, Nitriles, and H 2 by Heterogeneous Pt Catalysts
Author(s) -
Siddiki S. M. A. H.,
Touchy Abeda S.,
Bhosale Ashvini,
Toyao Takashi,
Mahara Yuji,
Ohyama Junya,
Satsuma Atsushi,
Shimizu Kenichi
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701355
Subject(s) - levulinic acid , catalysis , chemistry , substrate (aquarium) , reductive amination , combinatorial chemistry , solvent , turnover number , reusability , organic chemistry , medicinal chemistry , oceanography , software , computer science , programming language , geology
We report herein the first general catalytic system for the direct synthesis of N‐substituted γ‐ and δ‐lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H 2 under mild conditions (7 bar H 2 , 110 °C, solvent free). The most effective catalyst, Pt and MoO x co‐loaded TiO 2 (Pt‐MoO x /TiO 2 ), shows a wide substrate scope, high turnover number (TON), and good reusability.