Premium
Direct Synthesis of Lactams from Keto Acids, Nitriles, and H 2 by Heterogeneous Pt Catalysts
Author(s) -
Siddiki S. M. A. H.,
Touchy Abeda S.,
Bhosale Ashvini,
Toyao Takashi,
Mahara Yuji,
Ohyama Junya,
Satsuma Atsushi,
Shimizu Kenichi
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701355
Subject(s) - levulinic acid , catalysis , chemistry , substrate (aquarium) , reductive amination , combinatorial chemistry , solvent , turnover number , reusability , organic chemistry , medicinal chemistry , oceanography , software , computer science , programming language , geology
We report herein the first general catalytic system for the direct synthesis of N‐substituted γ‐ and δ‐lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H 2 under mild conditions (7 bar H 2 , 110 °C, solvent free). The most effective catalyst, Pt and MoO x co‐loaded TiO 2 (Pt‐MoO x /TiO 2 ), shows a wide substrate scope, high turnover number (TON), and good reusability.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom