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Inside Cover: One‐Pot Biocatalytic Double Oxidation of α‐Isophorone for the Synthesis of Ketoisophorone (ChemCatChem 17/2017)
Author(s) -
Tavanti Michele,
Parmeggiani Fabio,
Castellanos J. Rubén Gómez,
Mattevi Andrea,
Turner Nicholas J.
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701299
Subject(s) - isophorone , cascade , biocatalysis , allylic rearrangement , cover (algebra) , chemistry , combinatorial chemistry , organic chemistry , nanotechnology , catalysis , materials science , reaction mechanism , engineering , chromatography , mechanical engineering
The Cover shows the chemical structure of ketoisophorone (KIP), a valuable building block of vitamins, pharmaceuticals and APIs. In their Full Paper, M. Tavanti et al. describe the first biocatalytic cascade to access this key intermediate through the double allylic oxidation of the readily available α‐isophorone employing a variant of P450cam‐RhFRed and Cm‐ADH10. The designed cascade has been demonstrated both as a one‐pot two‐step process and as a cascade process employing designer cells co‐expressing the two biocatalysts, with a productivity of up to 1.4 g L −1 d −1 . More information can be found in the Full Paper by M. Tavanti et al. on page 3338 in Issue 17, 2017 (DOI: 10.1002/cctc.201700620).