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Hydrogenolysis of Amide Acetals and Iminium Esters
Author(s) -
Kadyrov Renat
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701287
Subject(s) - iminium , hydrogenolysis , amide , chemistry , nitrile , organic chemistry , catalysis , combinatorial chemistry
Amide acetals and iminium esters were hydrogenated into amines under very mild reaction conditions over common hydrogenation catalysts. This finding provides a new strategy for the selective reduction of amides. The synthetic utility of this approach was demonstrated by the selective reduction of amides bearing ester and nitrile groups.