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Coupling Molecular Photocatalysis to Enzymatic Conversion
Author(s) -
Mengele Alexander K.,
Seibold Gerd M.,
Eikmanns Bernhard J.,
Rau Sven
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701232
Subject(s) - moiety , chemistry , photocatalysis , cofactor , catalysis , ruthenium , photochemistry , combinatorial chemistry , enzyme catalysis , turnover number , ligand (biochemistry) , yield (engineering) , nad+ kinase , enzyme , stereochemistry , materials science , organic chemistry , biochemistry , receptor , metallurgy
A hetero‐binuclear dyad that contains a ruthenium polypyridyl moiety bound through an aromatic bridging ligand to an organometallic catalytic center has been used for the light‐driven reduction of the N ‐benzyl‐3‐carbamoylpyridinium cation, NAD + , and NADP + to yield the two‐electron‐reduced analog. Direct coupling with enzymatic conversion was proved by using UV/Vis spectroscopy and liquid chromatography, which showed cofactor‐recycling and enzymatic conversion with a turnover number of 350 per photocatalyst. First insights into the complex behavior of the catalytic system under irradiation point towards multiple prerequisites on the molecular as well as on the macroscopic level to generate highly efficient semiartificial photo‐biocatalytic systems for future energy‐storage applications.