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Back Cover: In Vivo Synthesis of Polyhydroxylated Compounds from a “Hidden Reservoir” of Toxic Aldehyde Species (ChemCatChem 15/2017)
Author(s) -
Bayer Thomas,
Milker Sofia,
Wiesinger Thomas,
Winkler Margit,
Mihovilovic Marko D.,
Rudroff Florian
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201701177
Subject(s) - aldehyde , aldolase a , aldehyde dehydrogenase , alcohol dehydrogenase , aldehyde reductase , carboxylic acid , chemistry , biocatalysis , alcohol , biotransformation , enzyme , escherichia coli , organic chemistry , biochemistry , catalysis , reductase , reaction mechanism , gene
The Cover shows a biochemical cell factory ( Escherichia coli ) for the synthesis of chiral polyhydroxylated compounds via an artificial enzyme cascade.In their Communication, T. Bayer et al. presented a rational approach for tuning the concentration of toxic aldehyde intermediates in living cells. By combining an alcohol dehydrogenase and a carboxylic acid reductase, the redox equilibrium between alcohol, aldehyde and carboxylic acid species can be adjusted, thus maintaining the aldehyde concentration in a ‘hidden reservoir’ and therefore below the toxicity level, yet freely available for subsequent aldolase mediated reaction. More information can be found in the Communication by T. Bayer et al. on page 2919 in Issue 15, 2017 (DOI: 10.1002/cctc.201700469).