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Ruthenium‐Catalyzed Deaminative Hydrogenation of Aliphatic and Aromatic Nitriles to Primary Alcohols
Author(s) -
Molnár István Gábor,
Calleja Pilar,
Ernst Martin,
Hashmi A. Stephen K.,
Schaub Thomas
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700878
Subject(s) - chemistry , ruthenium , catalysis , organic chemistry , selectivity , primary (astronomy) , nitrile , solvent , alcohol , physics , astronomy
The deaminative hydrogenation of nitriles towards alcohols is a useful reaction to transform nitriles into alcohols with NH 3 as the sole byproduct. Using the simple and robust RuHCl(CO)(PPh 3 ) 3 complex as a catalyst, at low H 2 pressures a series of aliphatic and aromatic nitriles could be transformed into the corresponding alcohols. Suitable solvent systems for these reactions were 1,4‐dioxane/water and EtOH/water mixtures. In most cases, the selectivity for the alcohols was excellent, and the corresponding amines were formed only in trace amounts.