Premium
Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones
Author(s) -
Aleku Godwin A.,
Nowicka Beatrycze,
Turner Nicholas J.
Publication year - 2018
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700685
Subject(s) - enzyme , chemistry , biocatalysis , synthetic biology , biosynthesis , mutagenesis , protein engineering , terpenoid , biochemistry , stereochemistry , biology , computational biology , gene , catalysis , reaction mechanism , mutation
Naturally occurring isoprenoid quinones mediate electron transfer in respiratory or photosynthetic chains of living organisms. Tremendous progress has been made in the elucidation of biosynthetic pathways of prenylated quinones and a number of enzymes that catalyze specific transformation steps with remarkably high regio‐ and stereoselectivity have been characterized. Interestingly, some of these enzymes possess broad substrate scope towards synthetic analogues, thereby enabling their application as synthetic tools. The availability of mechanistic, structural and mutagenesis information for many of the pathway enzymes presents opportunities for protein engineering, a powerful approach that may improve the suitability of these biocatalysts for industrial processes.