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Water‐Soluble Iridium N‐Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols
Author(s) -
Fernandes Ana,
Royo Beatriz
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700678
Subject(s) - alkylation , chemistry , carbene , iridium , amide , primary (astronomy) , catalysis , organic chemistry , substrate (aquarium) , combinatorial chemistry , functional group , physics , oceanography , polymer , astronomy , geology
A new series of water‐soluble Ir complexes with N‐heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.