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Back Cover: Separating Thermodynamics from Kinetics—A New Understanding of the Transketolase Reaction (ChemCatChem 10/2017)
Author(s) -
Marsden Stefan R.,
Gjonaj Lorina,
Eustace Stephen J.,
Hanefeld Ulf
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700555
Subject(s) - decarboxylation , transketolase , chemistry , kinetics , catalysis , substrate (aquarium) , product (mathematics) , thermodynamics , computational chemistry , organic chemistry , enzyme , physics , oceanography , geometry , mathematics , quantum mechanics , geology
The Cover shows the product time course for the transketolase catalyzed synthesis of l ‐erythrulose following a decarboxylation driven approach and a self‐reaction strategy.In their Full Paper, S. R. Marsden et al. demonstrate the separation of the thermodynamic contribution of decarboxylation from the product forming reaction. With both reaction pathways proceeding via the same intermediate, thermodynamic equilibration via the one‐substrate reaction pathway is the necessary consequence. Contrary to an irreversible product formation, transketolase catalyzed reactions driven by decarboxylation are therefore newly characterized as kinetically controlled. More information can be found in the Full Paper by S. R. Marsden et al. on page 1808 in Issue 10, 2017 (DOI: 10.1002/cctc.201601649).