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Palladium‐Catalyzed Ligand‐Controlled Selective Synthesis of Aldehydes and Acids from Aryl Halides and Formic Acid
Author(s) -
Wu FuPeng,
Peng JinBao,
Meng LingShen,
Qi Xinxin,
Wu XiaoFeng
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700517
Subject(s) - carbonylation , chemistry , carboxylation , palladium , catalysis , aryl , ligand (biochemistry) , denticity , formic acid , carboxylic acid , combinatorial chemistry , halide , organic chemistry , steric effects , aldehyde , carbon monoxide , metal , alkyl , biochemistry , receptor
Selective synthesis is in the core of modern organic chemistry. In this communication, a novel ligand‐dependent palladium‐catalyzed carbonylation procedure for the divergent synthesis of aldehydes and carboxylic acids from easily available aryl halides was established. Under the same reaction conditions, the reaction pathway could be controlled by the ligands applied to give formylated and carboxylated products selectively. Sterically hindered monodentate ligands facilitated the reductive carbonylation and provided aldehydes, whereas bidentate ligands preferred the carboxylation reaction and produced carboxylic acids. A wide range of functional groups were tolerated, and the products were, in general, obtained in moderate to excellent yields.