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Cover Picture: Immobilization of Alcohol Dehydrogenase from E. coli onto Mesoporous Silica for Application as a Cofactor Recycling System (ChemCatChem 7/2017)
Author(s) -
Dreifke Michael,
Brieler Felix J.,
Fröba Michael
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700463
Subject(s) - acetone , mesoporous material , chemistry , mesoporous silica , substrate (aquarium) , cofactor , alcohol dehydrogenase , aqueous solution , biocatalysis , immobilized enzyme , alcohol , catalysis , organic chemistry , enzyme , reaction mechanism , oceanography , geology
The Front Cover shows a single spherical cell of mesoporous cellular siliceous foams (MCF) with an immobilized alcohol dehydrogenase (ADH, green).In their Full Paper, M. Dreifke et al. demonstrate that the immobilized ADH is able to catalyze the oxidation of 2‐propanol to acetone with concomitant reduction of NADP + to NADPH in aqueous media (blue). However, the adsorptively bound ADH can also catalyze the reduction of acetone to 2‐propanol, accompanied by the oxidation of NADPH to NADP + . Depending on the substrate to be converted, 2‐propanol or acetone, energy is required or released (indicated in yellow). As the immobilization was carried out onto a mesoporous support, the substrate and coenzyme molecules have to diffuse through small windows into the porous network of the host to reach the immobilized enzyme.