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Palladium‐Catalyzed Direct Monoarylation of Aryl C−H Bonds with Iodoarenes
Author(s) -
Su Li,
Guo DongDong,
Li Bin,
Guo ShiHuan,
Pan GaoFei,
Gao YaRu,
Wang YongQiang
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201700138
Subject(s) - trifluoroacetic acid , catalysis , chemistry , palladium , aryl , substrate (aquarium) , combinatorial chemistry , transition metal , selectivity , stoichiometry , organic chemistry , alkyl , oceanography , geology
The transition‐metal‐catalyzed direct arylation of nonactivated aryl C−H bonds with iodoarenes has emerged as an important method for the construction of biaryls. Generally, the direct arylation reaction proceeds in the presence of stoichiometric Ag additives; moreover, the diarylation product is often unavoidable if there are two identical aromatic C−H bonds in the substrate. Herein we disclose an efficient Pd(OAc) 2 /trifluoroacetic acid/O 2 catalytic system that promotes direct arylation reactions of a variety of aromatic C−H bonds with diverse iodoarenes under Ag‐free conditions. The coupling reaction possesses a complete monoarylation selectivity. This approach provides a straightforward, facile, and economical route to biaryls.