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σ‐Alkyl‐Pd II Species for Remote C−H Functionalization
Author(s) -
Mehta Vaibhav P.,
GarcíaLópez JoséAntonio
Publication year - 2017
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201601624
Subject(s) - palladium , surface modification , moiety , alkyl , chemistry , domino , catalysis , stereochemistry , transition metal , cascade reaction , metal , combinatorial chemistry , organic chemistry
Abstract The transition‐metal‐directed C−H activation processes have traditionally required the installation of suitable coordinating groups to place the metal in close proximity to an specific neighboring or remote C(sp 2 )‐H or C(sp 3 )‐H moiety of the molecular structure. Alternatively, substitution of C−H bonds at positions previously thought inaccessible are now performed through domino processes via in situ generated σ‐alkyl‐Pd II species. This Concept article highlights on recent developments which utilize these σ‐alky‐Pd II ‐species for remote C−H functionalization to reinvigorate new C−C bond formation in cascade fashion via use of catalytic palladium metal.