Heterogeneous Chitosan@Copper(II)‐Catalyzed Remote Trifluoromethylation of Aminoquinolines with the Langlois Reagent by Radical Cross‐Coupling

The first remote C−H trifluoromethylation of N ‐(quinolin‐8‐yl)benzamide derivatives was accomplished with a user‐friendly chitosan‐based heterogeneous copper catalyst under mild conditions. The position‐selective C−H activation protocol afforded the corresponding coupling products in good to excellent yields with excellent reusability of the catalyst by using the low‐costing and stable Langlois reagent (CF 3 SO 2 Na) as the “CF 3 ” source. Furthermore, control experiments suggested a single‐electron‐transfer process played a vital role in the heterogeneous C−CF 3 cross‐coupling.