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Recent Progress in Metal Catalyzed Direct Carboxylation of Aryl Halides and Pseudo Halides Employing CO 2 : Opportunities for 11 C Radiochemistry
Author(s) -
Ahamed Muneer,
Verbeek Joost,
Funke Uta,
Lecina Joan,
Verbruggen Alfons,
Bormans Guy
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600943
Subject(s) - synthon , halide , aryl , catalysis , chemistry , carboxylation , carbon fibers , transition metal , organic chemistry , combinatorial chemistry , materials science , alkyl , composite number , composite material
Carbon dioxide (CO 2 ) as a synthon in organic transformations is very useful, especially when combined with transition metal catalysts. CO 2 insertion on carbon(Aryl)‐metal is are an elegant route to construct carbon–carbon bonds. A limited number of reports have been published to date on the direct conversion of aryl halides (or pseudo halides) to aryl carboxylic acids using transition metal catalysts. These reactions place great demand on the choice of catalyst, starting material, and reducing agent. However, these approaches could be of interest for the synthesis of a wide range of biologically active small molecules. Such transformations have already been applied for the synthesis of radiolabeled compounds for imaging with positron emission tomography (PET) using cyclotron produced [ 11 C]CO 2 and may be applicable to the production of a diverse range of PET tracers.