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Recent Developments in the Nitroxide‐Catalyzed Oxidation of Amines: Preparation of Imines and Nitriles
Author(s) -
Bartelson Ashley L.,
Lambert Kyle M.,
Bobbitt James M.,
Bailey William F.
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600858
Subject(s) - allylic rearrangement , catalysis , nitrile , chemistry , imine , nitroxide mediated radical polymerization , organic chemistry , combinatorial chemistry , reaction mechanism , polymer , polymerization , radical polymerization
This Concept highlights the discovery and developments in the oxidations of amines catalyzed by TEMPO (2,2,6,6‐tetramethylpiperidinyl‐ N ‐oxyl) and related catalytic systems. The most important feature of these systems is that, with slight modifications in the reaction media, amines are selectively oxidized to either an imine or nitrile. Progress made toward the oxidation of various benzylic, allylic, and aliphatic amines, and possible reaction mechanism pathways are discussed.