Premium
Attraction versus Repulsion in Rhodium‐Catalyzed Asymmetric Hydrogenation
Author(s) -
Gridnev Ilya D.
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600759
Subject(s) - asymmetric hydrogenation , catalysis , rhodium , chemistry , attraction , enantioselective synthesis , ligand (biochemistry) , substrate (aquarium) , non covalent interactions , organocatalysis , computational chemistry , combinatorial chemistry , organic chemistry , molecule , hydrogen bond , linguistics , philosophy , receptor , biochemistry , oceanography , geology
Abstract For several decades of intensive research it has been accepted that the physical sizes and shapes of substituents are the main stereoregulating factors in Rh‐catalyzed asymmetric hydrogenation. In this paper, it is argued on the basis of accumulated experimental and computational evidence that weak noncovalent attractive interactions between the substituents of the chiral ligand and the substrate strongly contribute to the process of stereoselection in Rh‐catalyzed asymmetric hydrogenation in the same fashion as that observed in organocatalytic reactions and in biological enzymatic processes.