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Boron Lewis Acid Promoted Ruthenium‐Catalyzed Hydrogenation of Amides: An Efficient Approach to Secondary Amines
Author(s) -
Yuan MingLei,
Xie JianHua,
Zhou QiLin
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600635
Subject(s) - triphos , catalysis , lewis acids and bases , chemistry , ruthenium , boron , selectivity , organic chemistry , medicinal chemistry , lewis acid catalysis
The hydrogenation of amides to amines has been developed by using the catalyst [Ru(H) 2 (CO)(Triphos)] (Triphos=1,1,1‐tri(diphenylphosphinomethyl)ethane) and catalytic boron Lewis acids such as B(C 6 F 5 ) 3 or BF 3 ⋅ Et 2 O as additives. The reaction provides an efficient method for the preparation of secondary amines from amides in good yields with high selectivity.