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Inside Cover: Modular Combination of Enzymatic Halogenation of Tryptophan with Suzuki–Miyaura Cross‐Coupling Reactions (ChemCatChem 10/2016)
Author(s) -
Frese Marcel,
Schnepel Christian,
Minges Hannah,
Voß Hauke,
Feiner Rebecca,
Sewald Norbert
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600526
Subject(s) - halogenation , chemistry , tryptophan , biocatalysis , regioselectivity , combinatorial chemistry , catalysis , substituent , halide , aryl , coupling reaction , organic chemistry , ionic liquid , amino acid , alkyl , biochemistry
The Cover highlights the cascade combination of biocatalysis with metal catalysis. In their Full Paper, M. Frese et al. explain that regioselective enzymatic halogenation of l ‐tryptophan followed by Suzuki‐Miyaura cross‐coupling leads, in a modular synthesis, to an array of C5, C6, or C7 aryl‐substituted tryptophan derivatives. The bromo substituent is initially being incorporated by immobilized tryptophan 5‐, 6‐, or 7‐halogenases, in aqueous media, using only oxygen and a halide source. Workup is not required: the solid biocatalyst is just removed by filtration and the filtrate is used to directly convert the halogenated tryptophan into the cross‐coupling products. More information can be found in the Full Paper by M. Frese et al. on page 1799 in Issue 10, 2016 (DOI: 10.1002/cctc.201600317).