Premium
Mechanochemical Enzymatic Kinetic Resolution of Secondary Alcohols under Ball‐Milling Conditions
Author(s) -
Hernández José G.,
Frings Marcus,
Bolm Carsten
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600455
Subject(s) - mechanosynthesis , candida antarctica , ball mill , biocatalysis , kinetic resolution , mechanochemistry , chemistry , lipase , chemical engineering , organic chemistry , kinetic energy , catalysis , enzyme , materials science , reaction mechanism , physics , enantioselective synthesis , quantum mechanics , engineering
Mechanosynthesis is a valuable technique, offering attractive alternatives for the preparation of organic, inorganic, and organometallic products. Surprisingly, mechanochemical enzymatic transformations have only scarcely been studied until now. Here, we demonstrate the use of lipase B from Candida antarctica (CALB) in acylative kinetic resolutions of secondary alcohols in mixer and planetary mills. Despite the mechanical stress caused by the high‐speed ball milling, the biocatalyst proved highly effective, stable, and, in part, recyclable under the applied mechanochemical conditions.