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Enantioselective Cu‐Catalyzed Functionalizations of Unactivated Alkenes
Author(s) -
Sorádová Zuzana,
Šebesta Radovan
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600252
Subject(s) - enantioselective synthesis , boranes , alkene , electrophile , chemistry , copper , hydride , borylation , catalysis , combinatorial chemistry , organic chemistry , boron , alkyl , metal , aryl
Copper hydride or copper boranyl species have already been used in reactions with Michael acceptors. Recently, notable advances have been described and the methodology extended to unactivated alkenes as well. In situ generated copper hydride ligated with chiral ligands is able to catalyze enantioselective aminations of alkenes. Furthermore, transient organocopper species formed upon initial hydrocupration of the alkene can be intercepted by other electrophiles such as imines, organohalides, or boranes.