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Rhodium‐Catalyzed/Copper‐Mediated Selective C2 Alkynylation of Indoles and C1 Alkynylation of Carbazoles with γ ‐Substituted tert ‐Propargyl Alcohols
Author(s) -
Li Ting,
Wang Zhen,
Qin WenBing,
Wen TingBin
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600218
Subject(s) - alkynylation , propargyl , rhodium , chemistry , catalysis , reagent , copper , organic chemistry , medicinal chemistry , combinatorial chemistry
A novel rhodium‐catalyzed/copper‐mediated C2‐selective C−H alkynylation of indoles using γ ‐substituted tert ‐propargyl alcohols as the alkynylating reagent and a removable 6‐methylpyridin‐2‐yl as the directing group has been developed, which provides a viable pathway for direct C2‐selective alkynylation of indoles. Moreover, this strategy could be extended to the C−H alkynylation of carbazoles at the C1 position.