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Carbon Nanotube–Ruthenium Hybrids for the Partial Reduction of 2‐Nitrochalcones: Easy Access to Quinoline N ‐Oxides
Author(s) -
Basu Pallabita,
Prakash Praveen,
Gravel Edmond,
Shah Nimesh,
Bera Kalisankar,
Doris Eric,
Namboothiri Irishi N. N.
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600042
Subject(s) - quinoline , hydroxylamine , ruthenium , catalysis , nitro , chemistry , intramolecular force , carbon nanotube , organic chemistry , combinatorial chemistry , photochemistry , materials science , nanotechnology , alkyl
A ruthenium–carbon nanotube nanohybrid was employed as a catalyst in the tandem transformation of nitrochalcones into quinoline N ‐oxides. Partial reduction of the nitro group to a hydroxylamine, followed by in situ intramolecular condensation to the carbonyl afforded the quinoline‐ N ‐oxides in satisfactory to good yields. Reduction of the nitro group was selective and independent of changes in the reaction conditions. Highlights of this method include a very low catalyst loading relative to that required for conventional methods for the synthesis of quinoline N ‐oxides and mild reaction conditions.