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Tunable Di‐ and Mono‐γ‐C−H Arylation of Phenylacetamides by Palladium‐Catalyzed Domino Reactions
Author(s) -
Liu Yunyun,
Huang Bin,
Cao Xiaoji,
Wan JiePing
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600039
Subject(s) - palladium , domino , catalysis , chemistry , selectivity , combinatorial chemistry , cascade reaction , medicinal chemistry , organic chemistry
The Pd‐catalyzed C−H arylation of phenylacetamides in the γ position was realized for the first time by means of a domino process consisting of in situ directing group installation and C−H arylation. Unprecedented tunable selectivity between di‐ and monoactivation of the two identical γ‐C−H bonds was achieved by modifying the reaction conditions; this is a distinct feature of this one‐pot procedure for the C−H‐activation‐based synthesis of diverse amides.