Tunable Di‐ and Mono‐γ‐C−H Arylation of Phenylacetamides by Palladium‐Catalyzed Domino Reactions | Zendy

Liu Yunyun | Zendy; Huang Bin | Zendy; Cao Xiaoji | Zendy; Wan JiePing | Zendy

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Tunable Di‐ and Mono‐γ‐C−H Arylation of Phenylacetamides by Palladium‐Catalyzed Domino Reactions

Author(s) -

Liu Yunyun,

Huang Bin,

Cao Xiaoji,

Wan JiePing

Publication year - 2016

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201600039

Subject(s) - palladium , domino , catalysis , chemistry , selectivity , combinatorial chemistry , cascade reaction , medicinal chemistry , organic chemistry

The Pd‐catalyzed C−H arylation of phenylacetamides in the γ position was realized for the first time by means of a domino process consisting of in situ directing group installation and C−H arylation. Unprecedented tunable selectivity between di‐ and monoactivation of the two identical γ‐C−H bonds was achieved by modifying the reaction conditions; this is a distinct feature of this one‐pot procedure for the C−H‐activation‐based synthesis of diverse amides.

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