Metal–Organic Framework Capillary Microreactor for Application in Click Chemistry

A Cu/PMA–MIL‐101(Cr) metal–organic‐framework‐coated microreactor has been applied in the 1,3‐dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA–MIL‐101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA–MIL‐101(Cr) capillary microreactor in the click‐chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time‐on‐stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.