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Metal–Organic Framework Capillary Microreactor for Application in Click Chemistry
Author(s) -
Truter Lara A.,
JuanAlcañiz Jana,
Kapteijn Freek,
Nijhuis Tjeerd A.,
Gascon Jorge,
Schouten Jaap C.
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201600016
Subject(s) - microreactor , click chemistry , catalysis , chemistry , reagent , cycloaddition , chemical engineering , metal organic framework , coating , green chemistry , organic chemistry , inorganic chemistry , reaction mechanism , adsorption , engineering
A Cu/PMA–MIL‐101(Cr) metal–organic‐framework‐coated microreactor has been applied in the 1,3‐dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA–MIL‐101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA–MIL‐101(Cr) capillary microreactor in the click‐chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time‐on‐stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.