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Inside Back Cover: Chiral Chlorohydrins from the Biocatalyzed Reduction of Chloroketones: Chiral Building Blocks for Antiretroviral Drugs (ChemCatChem 6/2015)
Author(s) -
de Miranda Amanda S.,
Simon Robert C.,
Grischek Barbara,
de Paula Gabriel C.,
Horta Bruno A. C.,
de Miranda Leandro S. M.,
Kroutil Wolfgang,
Kappe C. Oliver,
de Souza Rodrigo O. M. A.
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201590034
Subject(s) - biocatalysis , cover (algebra) , chemistry , combinatorial chemistry , alcohol dehydrogenase , substrate (aquarium) , organic chemistry , alcohol , catalysis , reaction mechanism , biology , engineering , mechanical engineering , ecology
The cover picture shows how a single alcohol dehydrogenase is able to reduce structurally related chloroketones derived from S ‐amino acids with the opposite enantiopreference to furnish both ( R , S ) and ( S , S )‐chlorohydrins. In their Full Paper, de Miranda et al. describe how stereocontrol can be achieved by changing the N‐protecting group in the substrate, allowing the preparation of stereocomplementary halohydrins by using the same biocatalyst. The article highlighted by this cover can be found on p. 984 ff. of Issue 6, 2015.