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Back Cover: One‐pot Conversion of Cycloalkanes to Lactones (ChemCatChem 2/2015)
Author(s) -
Pennec Alizé,
Hollmann Frank,
Smit Martha S.,
Opperman Diederik J.
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201590011
Subject(s) - monooxygenase , biocatalysis , cofactor , chemistry , ketone , cycloalkane , redox , cover (algebra) , alcohol dehydrogenase , baeyer–villiger oxidation , stereochemistry , organic chemistry , catalysis , alcohol , cytochrome p450 , reaction mechanism , enzyme , mechanical engineering , engineering
The cover picture shows the one‐pot conversion of cycloalkanes to lactones. In their Communication, A. Pennec et al. describe a redox‐balanced synthetic pathway consisting of a cytochrome P450 monooxygenase (CYP450) for initial oxyfunctionalization of the cycloalkane, an alcohol dehydrogenase for ketone production and a Baeyer–Villiger monooxygenase for lactone formation. Product yields were increased by uncoupling the co‐factor requirements between the multiple oxidation reduction steps through variation of the cofactor dependence of the biocatalysts and the cofactor regeneration system. The article highlighted by this cover can be found on p. 236 ff. of Issue 2, 2015.