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Cover Picture: Catalyst‐Controlled Selectivity in C−S Bond Formation: Highly Efficient Synthesis of C2‐ and C3‐Sulfonylindoles (ChemCatChem 2/2016)
Author(s) -
Yang Yong,
Li Wanmei,
Xia Chengcai,
Ying Beibei,
Shen Chao,
Zhang Pengfei
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501391
Subject(s) - regioselectivity , catalysis , chemistry , electrophile , nucleophile , selectivity , sodium iodide , copper , combinatorial chemistry , iodide , medicinal chemistry , organic chemistry
The Front Cover shows two different methods to accomplish C−S bond formation for highly effective synthesis of C2‐ and C3‐sulfonylindoles. In their Communication, Y. Yang et al. demonstrate an unprecedented regioselective sulfonylation reaction of indoles with sodium sulfinates through electrophilic addition to copper and nucleophilic attack of p ‐toluenesulfonyl iodides. The two facile and efficient strategies use copper salt and iodide catalysts, respectively, and this method features easy operation, excellent yields, and cheap catalysts. The current investigation gave significant directive to promote further study of synthetic regioselectivity. More information can be found in the Communication by Y. Yang et al. on page 304 in Issue 2, 2016 (DOI: 10.1002/cctc.201500917).