Premium
Organoselenium‐Catalyzed Oxidative Ring Expansion of Methylenecyclopropanes with Hydrogen Peroxide
Author(s) -
Yu Lei,
Chen Fenglin,
Ding Yuanhua
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501309
Subject(s) - hydrogen peroxide , ring (chemistry) , catalysis , chemistry , oxidative phosphorylation , combinatorial chemistry , peroxide , medicinal chemistry , organic chemistry , biochemistry
Catalyst screening and optimization of reaction conditions allowed control of the organoselenium‐catalyzed oxidative ring expansion of highly active methylenecyclopropanes to give substituted cyclobutanones selectively. This protocol employs H 2 O 2 as a clean oxidant and generates no waste and, therefore, provides green access to useful, but not readily available, substituted cyclobutanones under mild conditions.