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Methyltransferases: Green Catalysts for Friedel–Crafts Alkylations
Author(s) -
Tengg Martin,
Stecher Harald,
Offner Lisa,
Plasch Katharina,
Anderl Felix,
Weber Hansjörg,
Schwab Helmut,
GruberKhadjawi Mandana
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501306
Subject(s) - friedel–crafts reaction , alkylation , chemistry , cofactor , catalysis , biotransformation , biocatalysis , methyltransferase , enzyme , organic chemistry , substrate (aquarium) , enzyme catalysis , methyl group , alkyl , stereochemistry , combinatorial chemistry , reaction mechanism , methylation , biochemistry , biology , ecology , gene
A set of S ‐adenosyl‐ l ‐methionine (SAM) dependent methyltransferases has been characterized as versatile catalysts for the enzymatic Friedel–Crafts (alkylation) reaction. Although the substrate specificity of the enzymes range from high (in the case of SfmM2, SacF, and ORF19) to moderate (in the case of NovO and CouO), the cofactor spectrum is broad. Modified cofactors decorated with alkyl groups other than methyl were used for biocatalytic Friedel–Crafts alkylation, and conversions up to 99 % were achieved. In contrast to the classical chemical reaction the biotransformation is very selective and environmentally compatible.