Premium
Inside Back Cover: Chemoenzymatic Deracemization of Secondary Alcohols by using a TEMPO–Iodine–Alcohol Dehydrogenase System (ChemCatChem 24/2015)
Author(s) -
MéndezSánchez Daniel,
MangasSánchez Juan,
Lavandera Iván,
Gotor Vicente,
GotorFernández Vicente
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501289
Subject(s) - enantiopure drug , chemistry , biocatalysis , iodine , alcohol dehydrogenase , alcohol oxidation , alcohol , organic chemistry , combinatorial chemistry , catalysis , reaction mechanism , enantioselective synthesis
The Cover shows an efficient chemoenzymatic deracemization system of secondary alcohols based on a one‐pot two‐step procedure. In their Communication, Méndez‐Sánchez et al. show the benefits of ultrasound radiation for the quantitative non‐selective oxidation of aliphatic and aromatic alcohols into the corresponding ketones in aqueous media mediated by 2,2,6,6‐tetramethyl‐1‐piperidinyloxyl (TEMPO) and iodine. The proper selection of an ( R ) or ( S )‐selective alcohol dehydrogenase in the second step allows the isolation of the enantiopure alcohols with excellent yields, after elimination of excess iodine by simple reaction with Na 2 S 2 O 3 . More details can be found in the Communication by Méndez‐Sánchez et al. on page 4016 in Issue 24, 2015 (DOI: 10.1002/cctc.201500816).