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Room‐Temperature Hydration of Alkynes Catalyzed by Different Carbene Gold Complexes and their Precursors
Author(s) -
Xu Yun,
Hu Xingbang,
Zhang Shufeng,
Xi Xiuxing,
Wu Youting
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501065
Subject(s) - carbene , catalysis , chemistry , isocyanide , medicinal chemistry , nitrogen , alkyne , polymer chemistry , organic chemistry
The room‐temperature hydration of alkynes catalyzed by NHC‐gold(I) (NHC=N‐heterocyclic carbene), NAC‐gold(I) (NAC=nitrogen acyclic carbene), and isocyanide gold(I) complexes was investigated carefully in the presence of different weakly coordinating anions. NHC(IPr)‐AuCl/KB(C 6 F 5 ) 4 (NHC(IPr)=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene) was found to be the most active catalyst at room temperature, and the room‐temperature hydration of different alkynes could be completed in 7 h using only 0.5 mol % NHC(IPr)‐AuCl/KB(C 6 F 5 ) 4 . It was further demonstrated that the catalyst system could be simply reused at least six times without a noticeable loss of catalytic activity.