Premium
Inside Cover: Cascade Coupling of Ene‐Reductases and ω‐Transaminases for the Stereoselective Synthesis of Diastereomerically Enriched Amines (ChemCatChem 19/2015)
Author(s) -
Monti Daniela,
Forchin Maria Chiara,
Crotti Michele,
Parmeggiani Fabio,
Gatti Francesco G.,
Brenna Elisabetta,
Riva Sergio
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201501031
Subject(s) - stereoselectivity , reductive amination , stereocenter , ene reaction , chemistry , amination , amine gas treating , cascade reaction , cascade , coupling reaction , coupling (piping) , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , materials science , chromatography , metallurgy
The Cover shows the one‐pot coupling of ene‐reductases and ω‐transaminases to achieve the biocatalytic synthesis of diastereomerically enriched ( R )‐ and ( S )‐amines containing an additional stereocenter starting from either α‐ or β‐substituted unsaturated ketones as substrates. In their Communication, S. Riva and co‐workers demonstrate that the amine products can be obtained with excellent stereoselectivity and up to quantitative conversion in sequential and even cascade processes, with no need to adapt the reaction conditions to the reductive amination step or to purify the reaction intermediates. More details can be found in the Communication by S. Riva et al. on page 3106 in Issue 19, 2015 (DOI: 10.1002/cctc.201500424).