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Catalyst‐Controlled Selectivity in C−S Bond Formation: Highly Efficient Synthesis of C2‐ and C3‐Sulfonylindoles
Author(s) -
Yang Yong,
Li Wanmei,
Xia Chengcai,
Ying Beibei,
Shen Chao,
Zhang Pengfei
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500917
Subject(s) - selectivity , catalysis , chemistry , combinatorial chemistry , iodide , copper , organic chemistry
Exploring a potential catalyst system for catalyst‐controlled selectivity in C−S bond formation is a fascinating challenge. Herein, we described two novel and highly efficient methods for the selective synthesis of C2‐ and C3‐sulfonylindoles showing good biological activities by employing iodide and copper catalysts, respectively. Mechanistic studies point to the crucial role of the electronic properties of the sulfonylated intermediates.