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Organic Solvent Nanofiltration‐Supported Purification of Organocatalysts
Author(s) -
Großeheilmann Julia,
Fahrenwaldt Thomas,
Kragl Udo
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500902
Subject(s) - nanofiltration , solvent , catalysis , chemistry , organic solvent , enantioselective synthesis , membrane , organic chemistry , chromatography , chemical engineering , biochemistry , engineering
In this study, the successful use of organic solvent nanofiltration for the purification of three highly enantioselective quinine‐based organocatalysts was demonstrated. Commercially available solvent‐resistant membranes (DuraMem series) were utilized to remove specific impurities that originated from their respective synthesis pathways. DuraMem 200 exhibited the highest catalyst retention of 99 %, which facilitated catalyst purification at the gram scale with a purity >99 %.