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Polymers and Kinetic Resolutions: The Insolubility of It All
Author(s) -
Clark Robert W.,
Akhani Ravish K.,
Wiskur Sheryl L.
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500887
Subject(s) - kinetic resolution , polymer , macromolecule , chemistry , enantiomer , kinetic energy , combinatorial chemistry , catalysis , organic chemistry , enantioselective synthesis , biochemistry , physics , quantum mechanics
Kinetic resolution is a powerful technique to obtain enantioenriched compounds. A major drawback to conventional kinetic resolutions is that the final purification step to isolate the stereoenriched compounds usually employs chromatography, which is costly and difficult to perform on an industrial scale. Recent advances have demonstrated the applicability of polymer supports as a means of separating enantiomerically enriched starting materials from products in kinetic resolutions by having one enantiomer attached to the polymer and the other in solution. Herein, several approaches are reviewed in which either homogenous or heterogeneous macromolecules are employed to facilitate a chromatography‐free isolation of stereoenriched compounds. Kinetic resolutions employing enzymatic, transition‐metal, or small‐molecule‐catalyzed reactions by using polymeric materials will be discussed.